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kinesin spindle protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kinesin (11) ADC Linker (1) Apoptosis (6) Lipoxygenase (1)
By Research Areas:	Cancer (10) Neurological Disease (1)

11

Inhibitors & Agonists

2

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

Targets Recommended: Kinesin Mps1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Filanesib 5 Publications Verification ARRY-520	Kinesin Apoptosis	Cancer
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-124790

KSP-IA

Kinesin Cancer

KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

NHS-Ala-Ala-Asn-active metabolite	ADC Linker Kinesin	Cancer
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .

Filanesib hydrochloride ARRY-520 hydrochloride	Kinesin Apoptosis	Neurological Disease
Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

Filanesib TFA ARRY-520 TFA	Kinesin	Cancer
Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .

MK-0731	Kinesin Apoptosis Lipoxygenase	Cancer
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 2.2 nM and a pK_a of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .

HY-50759

Ispinesib

5 Publications Verification

SB-715992
Kinesin Apoptosis Cancer

Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

(R)-Filanesib (R)-ARRY-520	Kinesin	Cancer
(R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 6 nM.

Ispinesib-d5 SB-715992-d₅	Kinesin Apoptosis	Cancer
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

AZD4877	Kinesin Apoptosis	Cancer
AZD4877 is another isostere to Ispinesib (HY-50759)and also a *kinesin* spindle protein (Eg5) inhibitor with IC₅₀ of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .

PVZB1194	Kinesin	Cancer
PVZB1194 is a biphenyl-type inhibitor of *Kinesin* **spindle protein Eg5 or KIF11**. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	KIF11 Protein, Human KIF11; kinesin-like protein KIF11; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human is the recombinant human-derived KIF11 protein, expressed by E. coli , with tag free. The total length of KIF11 Protein, Human is 368 a.a., .

	KIF11 Protein, Human (His) KIF11; kinesin-like protein KIF11; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human (His) is the recombinant human-derived KIF11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of KIF11 Protein, Human (His) is 368 a.a., .

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